We know some things, but only about savants who really are totally nonfunctional except for their talents and about child geniuses. In both people, parts of their brains totally, totally overwhelm other parts because of development or disease or injury.

There's current work done on creativity and FMRI, which would show what parts of your brain are working when you're being creative, but it seems, pretty much, that anyone is capable of being creative. Just like everyone is capable of lying, unless they're damaged something.