After trying and not liking quality or service with the two big Print-on-demand services (Cafe Press and Zazzle) I've moved to Printfection.
Why it works for Artists: No fees! No charge for setup, No charge for keeping your site up, No tiered shops (free vs pay)
You decide your percentage of profits
You can control what colours, sizes, etc, of product you offer to customers.
No third party sales of your work
No use of your artwork as a template (No changes to your artwork by other users of the site)
Payment by check twice monthly
High quality for your customers
International shipping and payment options for customers
Shopkeeper and Customer Support
Bulk Discounts
Why it works for CustomersHigh quality merchandise (no peeling, cracking on tees, etc,)
Ability to chose various colours on clothing
No extra shipping charges (other sites use separate vendors for mugs vs tees, etc.)
Secure online payment options International and Domestic
Great (and fast) customer service - Easy returns
Frequent sales!
Bulk Discounts
Printfection does not offer all the selections of product of some sites, however, I've found most customers want to order tees, mugs and mousepads from me, rather than snowboards!
http://www.printfection.com/